The Molluscicidal activity of 5 pesticides, two acids (acetylsalicylic acid and tannic acid) and their combinations were studied against two land snail species under laboratory and field conditions. Results showed that abamectin was the most toxic one when used as a bait or contact against both species.The combination of acetylsalicylic acid with methomyl as a bait gave high potency effect (100% co-toxicity) factor against the two snail species. The effect of tested compounds on the biochemical parameters were determined. Results showed that the combination of acetylsalicylic acid and methomyl exhibited the highest effect on all biochemical parameter. The LC50 of acetylsalicylic acid caused desiccation and adhesive for snail body of both species while tannic acid caused intense damage in the shell and cannibalism effect for E. vermiculata, while it caused dryness and change in the body color of M. obstructa. The histopathological effects of LC50 of acetylsalicylic acid on the tissues of mucous gland was studied in both snail species. It was partial as well as complete disappearance, necrosis and atrophy of mucous glandular tissue for E. vermiculata and Monacha obstructa.